UNISTAT 10.11 統計分析套裝軟體
- UNISTAT 10.11 統計分析套裝軟體
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類別統計分析軟體
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介紹UNISTAT是視窗型統計分析軟體，運行於Windows平臺之上，其統計分析功能齊全、多種運行模式、介面友好、可操作性強、資料輸人輸出靈活。
UNISTAT 10.11 Statistical Analysis Software Suite
Stepwise Regression:
A new output option Run with Linear Regression was added
to Stepwise Regression for extended output.
Logit / Probit / Gompit Regression
Extended Weighted ANOVA table and weighted R-squared test
were added to Logit / Probit / Gompit.
90% confidence interval for regression coefficients was made
default for binary and aggregate dependent variable models,
but that can be changed by the user.
Case (Diagnostic) Statistics: Deviance residuals are now
displayed for binary and aggregate dependent variable
models.Heterogeneity factor (or dispersion parameter) can
now be estimated for binary and aggregate dependent
variable models, based on Deviance or Pearson statistics.
ED50 option (and its confidence limits), when there is only
one independent variable, has been removed. This is already
fully covered in Quantal Response Method procedure.
Analysis of Bioassays (all procedures)
Dose prediction: This is a new feature in Case(Diagnostic)
Statistics output of all bioassays analysis procedures supported
here. A response prediction facility has already been available
in all previous versions of UNISTAT’s Bioassay Module. In a
row with no other missing values, if only the dose value is
missing, then the dose value will be calculated using the
estimated model parameters. When a dose value is predicted,
its row label will be prefixed by an ampersand (&). See section
10.0.7. Prediction, Interpolation, Extrapolation.
Display of any Pass/Fail test can now be suppressed by enterin
g a threshold of -1 under the [Bioassay] section of Unistat.ini
file. See Display test results Pass/Fail and Display test details
under section 10.0.5.1. Compliance Output.
Potency confidence limits testing: The new Pass/Fail column
on Percent Confidence Interval output tests whether the lower
limit is greater than or equal to 75% AND the upper limit is less
than or equal to 125% by default. If one of these two results is
Fail, then the overall result will also be Fail. These default perce
ntage values can be changed by the user. It is also possible to
test only the lower limit against a given lower threshold or only
the upper limit against another upper threshold. See Display
test results Pass/Fail and Display test details under section 10.0.
5.1. Compliance Output.
Individual non-linearity statistics for preparations:
All bioassay procedures will report non-linearity tests for
individual preparations, as well as the overall non-linearity
for all preparations. It is possible not to display the individual
non-linearity values. See section 10.1.2.5. Validity of Assay.
Treatments in ANOVA tables: A Pass/Fail test was added.
Procedure headers:Valid and omitted number of cases are
reported. If a column has been selected by the Select Row
function, deselected cases are also reported separately.
Unistat10.ini settings:All settings concerning bioassay
procedures have now been made subject to Compliance
rules and are stored under the [Bioassay] section of the
following file:
C:\ProgramData\Unistat\Unistat10\Unistat10.ini instead
of:
C:\Users\…\Documents\Unistat10\Unistat10.ini
Compliance: A fixed UNISTAT version line added to headers
and footers. User-defined Main Title and Sub Title are now
under the header, replacing the procedure name.
Parallel Line and Slope Ratio Methods
An optional [Plate] variable has been added to Parallel Line
Method and Slope Ratio Method Variable Selection Dialogue
s. This usually helps to isolate the plate effect or the effect of
replicates. If all dose/treatment groups (or cells) have an
equal num ber of replicates, or if the design is balanced,
then the plate effect is equivalent to Randomised Block
Design.
Plots for both methods have been improved as Dose-
Response Plot with choice of Means with Error Bars or
Data Points plot options and trend line with confidence
limits.
Quantal Response Method
Extended Weighted ANOVA table and weighted R-squared
test was added to Quantal Response Method.
Four-Parameter Logistic Model
EP (European Pharmacopoeia) option:
An optional [Plate] variable was added, enabling
testing of plate and replicate effects and Randomised
Block Design.
Extended Weighted ANOVA table and weighted
R-squared test was added.
The ANOVA of Regression table, including an
unweighted R-squared test, was added.
Reduced Model USP:Goodness of Fit output options were
re-arranged and parallelism tests replaced by a full
ANOVA table as described by Gottschalk, P. G. and Dunn,
J. R. (2005).
A USP Summary option was added, combining Full and
Reduced USP models.
Combination of Assays
The Combination of Assays procedure formerly required
confidence limits and degrees of freedom data of all
potencies to be combined. Now, a variable selection
option Only Potencies are Given is added, enabling
the user to combine potencies without any accompanying
information.
The new optional variable [Preparation] enables combining
potencies belonging to different test samples separately.
Plot of Potencies has now options to draw mean and
confidence interval lines of the calculated mean potency
as well as individual potencies with error bars.
系統需求
UNISTAT 10.11 runs on 32-bit and 64-bit Windows 7, 8, 10 and Windows 2003-2016 Server. UNISTAT add-in runs on Excel 1997-2013 and 32-bit and 64-bit Excel 2010-2019. Unistat 10 is fully compatible with Office 365 desktop.
UNISTAT 10.11 統計分析套裝軟體
逐步回歸：
一個新的輸出選項Run with Linear Regression被添加到Stepwise Regression 以擴展輸出。
Logit / Probit / Gompit 回歸
擴展加權方差分析 表和加權 R 方檢驗被添加到Logit/Probit/Gompit。
回歸係數的 90% 置信區間是二元和聚合因變量模型的默認值，但用戶可以更改。
案例（診斷）統計：現在顯示二元和聚合因變量模型的偏差殘差。
現在可以基於Deviance或Pearson統計為二元和聚合因變量模型估計異質性因子（或分散參數）。
當只有一個自變量時，ED50 選項（及其置信限）已被刪除。這在量子響應方法 程序中已經完全涵蓋。
生物測定分析（所有程序）
劑量預測：這是此處支持的所有生物測定分析程序的病例（診斷）統計
輸出中的新功能。所有以前版本的 UNISTAT 生物測定模塊中都已提供
響應預測功能。在沒有其他缺失值的行中，如果僅缺失劑量值，則將使
用估計的模型參數計算劑量值。預測劑量值時，其行標籤將以與號 (&)
為前綴。見第10.0.7節。預測、內插、外推。
現在可以通過在Unistat.ini文件的 [ Bioassay ] 部分輸入閾值 -1 來抑
制任何通過/失敗測試的顯示。請參閱第10.0.5.1節下的顯示測試結果
通過/失敗和顯示測試詳細信息。合規性輸出。
效力置信限測試：百分比置信區間輸出上的新通過/失敗列測試下限是
否大於或等於 75% 以及上限是否默認小於或等於 125%。如果這兩個
結果之一是Fail，那麼總體結果也將是Fail。用戶可以更改這些默認百分
比值。也可以僅根據給定的下閾值測試下限或僅針對另一個上限測試上
限。請參閱第10.0.5.1節下的顯示測試結果通過/失敗 和顯示測試詳細信
息。合規性輸出。
製劑的個體非線性統計：所有生物測定程序都會報告個體製劑的非線性
測試，以及所有製劑的整體非線性。可以不顯示各個非線性值。
見第10.1.2.5節。測定的有效性。
在ANOVA表處理： 一個合格/不合格加入測試。
程序標題：報告有效和遺漏的案例數。如果“選擇行” 功能已選擇一
列，則也會單獨報告取消選擇的案例。
Unistat10.ini 設置：關於生物測定程序的所有設置現在都符合合規
性規則，並存儲在以下文件的 [Bioassay] 部分：
C:\ProgramData\Unistat\Unistat10\Unistat10.ini
而不是：
C:\用戶\...\Documents\Unistat10\Unistat10.ini
合規性：添加到頁眉和頁腳的固定 UNISTAT 版本行。用戶定義的主
標題和副標題 現在位於標題下，替換了過程名稱。
平行線和斜率比方法
一個可選的[播噸E]變量已被添加到平行線的方法 和斜率比法 變量選擇
對話秒。這通常有助於隔離板效應或重複的效應。如果所有劑量/治療
組（或細胞）具有相同數量的重複，或者如果設計是平衡的，則板效應
等同於隨機區組設計。
兩種方法的圖都已改進為劑量響應圖，可選擇帶誤差條的均值或數據點
圖選項和帶置信限的趨勢線。
量子響應法
擴展加權方差分析 表和加權 R 平方檢驗被添加到量子響應方法。
四參數邏輯模型
EP（歐洲藥典）選項：
添加了一個可選的 [Pla t e] 變量，可以測試板和重複效應以及隨
機區組設計。
添加了擴展加權方差分析 表和加權 R 平方檢驗。
添加了回歸表的方差分析，包括未加權的 R 方檢驗。
簡化模型 USP： 重新安排了擬合優度輸出選項，並用 Gottschalk,
PG和 Dunn, JR (2005) 所述的完整 ANOVA 表替換了並行
性測試。
一個USP摘要 加入選項，結合完整和減少USP模型。
組合檢測
該測定法的組合過程以前需要的置信界限和度所有效力的自由數據的
要被組合。現在，添加了一個變量選擇選項Only Potencies are
given，使用戶能夠在沒有任何附帶信息的情況下組合效力。
新的可選變量 [Preparation] 可以分別組合屬於不同測試樣本的效
力。
Plot of Potencies現在可以選擇繪製計算出的平均效力的均值和置
信區間線，以及帶有誤差線的單個效力。
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